Spondyloarthritis Clinical Research
Spondyloarthritis (also known as spondyloarthropathy) is an umbrella term that refers to a group of inflammatory rheumatic diseases that attack the joints. The inflammation leads to chronic pain that can be difficult to treat over the long run. Our research team is conducting spondyloarthritis clinical trials to help improve available medicine for these conditions.
(Are you interested in participating in a spondyloarthritis clinical trial? Please click on the link above or give us a call at (205) 757-8208.)
Spondyloarthritis differ from other types of arthritis, because they attack the part of the joint where the ligaments and tendons attach to the bone (known as the entheses). The most common types of spondyloarthropathy are:
- Ankylosing spondylitis
- Reactive arthritis
- Psoriatic arthritis
- Enteropathic arthritis
The symptoms of spondyloarthritis can manifest in two primary ways:
- Inflammation that causes chronic pain and stiffness.
- Bone destruction that can cause spinal deformities and decreased mobility in the hips and shoulders.
What Causes Spondyloarthritis?
Clinical research has shown that genetics can play a strong role in the development of spondyloarthritis. As many as 30 genes have been shown to cause these rheumatic conditions. The most common being HLA-B27 and nearly every patient diagnosed with ankylosing spondylitis has this gene.
People living with this gene are also more likely to develop enteropathic arthritis. This condition can present as Crohn’s disease and ulcerative colitis. However, the exact trigger for these diseases is still unclear. Researchers theorize that it is related to bacteria that enters the bowls when inflammation damages it.
Fast Facts on Spondyloarthritis
- Most patients suffer from pain and swelling in the arms and legs (peripheral spondyloarthritis)
- Your risk is higher if you have a family member with spondyloarthritis
- Most cases are diagnosed in males in their teens and 20s
- Patients with axial spondyloarthritis often develop spinal fusion (ankylosing spondylitis)
- Most spondyloarthritis patients suffer from low back pain
- More advanced treatments have proven effective at managing symptoms when combined with healthy lifestyle habits
The symptoms of spondyloarthritis often start in adolescents and 20 year olds. Studies have also shown that these conditions are two to three times more common in men.
Complications from Spondyloarthritis
Patients with spondyloarthritis can develop a range of additional complications. These can include:
- Nearly 50 percent of patients with ankylosing spondylitis develop osteoporosis, particularly those whose spine has fused.
- 40 percent of spondyloarthritis patients suffer from uveitis, an inflammation in part of the eye. The symptoms of uveitis include pain and redness in the affected eye.
- Patients are also at risk for inflammation in the heart’s aortic valve. Make sure that your heart is being checked regularly when you visit your doctor.
- Patients are at increased risk for psoriasis, an autoimmune disease that affects the skin. This disease can be severe and will require treatment.
- Patients who develop intestinal inflammation should make an appointment with a gastroenterologist for proper treatment.
Spondyloarthritis Clinical Trials in Birmingham, Alabama
Are you interested in participating in a spondyloarthritis clinical trial? We want to help get you enrolled in the most appropriate study. If you haven’t taken part in a clinical trial before, we do recommend checking out our participant resource section. The information on those pages can help answer many common questions about participating in clinical trials.
Participants will be compensated for the travel and time involved. The following will all be provided free of charge:
- Physical examinations
- Study prescribed medication
- Protocol mandated laboratory tests
Our medical staff is conducting clinical trials targeted towards a diverse array of clinical indications at our clinic in Birmingham. So we aren’t just looking to enroll spondyloarthritis patients for our clinical trials. If you are interested in helping us advance modern medicine while also earning money for your effort, please give us a call today at (205) 757-8208.
Some Additional Resources on Spondyloarthritis
- The American College of Rheumatology
- The Arthritis Foundation
- Info about Juvenile Spondyloarthritis
- Videos on Spondyloarthritis