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Cold Sore Clinical Research

Learn about Achieve's Cold Sores Clinical Trials

Woman considers a cold sore clinical research study after an HSV outbreakCold sores are something no one wants to see when they look in the mirror, but the truth is that they are pretty common. The condition, also referred to as fever blisters, are small blisters that manifest on the lips and around the mouth. These sores are a source of great embarrassment for many people, so we are conducting clinical trials in order to help advance medicine in this field.

(Are you interested in participating in a cold sore clinical trial? Please click on the link above or give us a call at (205) 757-8208.)

During an outbreak, the skin surrounding the blister will become inflamed and sore. The cold sore can also open and leak a clear fluid. It will then scab over and heal within a week or so. The blisters are caused by the herpes simplex virus (HSV). Cold sore clinical research has shown that there are two strains of the virus: HSV-1 and HSV-2. They both produce sores around the mouth in the people they infect.

What Causes a Cold Sore?

The herpes simplex virus is quite common. Do you get recurrent cold sores? It’s possible to contract the virus during childhood. HSV can enter the body through any skin lesion around or inside the mouth. Cold sore clinical research also shows that the most common source of infections is touching the blister or the fluid it produces.

This could occur when:

  • Kissing someone with a cold sore
  • Sharing razors or even eating utensils
  • Coming in contact with infected saliva

Parents living with this virus should take extra precautions to protect their children from the infection. Even though the virus doesn’t always produce any physical symptoms, there is still no cure for HSV.

Despite what we have learned from cold sore research studies, it’s unclear why some develop blisters and others don’t. Additionally, the name “cold sores” can be misleading as an outbreak can be triggered by a variety of factors, including:

  • Infections
  • Stress
  • Fever
  • Sunlight
  • Hormonal fluctuations
  • Certain foods
  • Medications

(Cold sore clinical research has shown that triggers remain unpredictable in many patients.)

What medical experts do know is that HSV follows a specific path of development after entering the host:

  • The virus reactivates after an initial period of dormancy
  • The virus uses the nerve endings to travel to the original point of infection– the patient’s mouth
  • The point of manifestation will start to itch, burn and tingle
  • A day later, a red bump will form
  • This bump then develops into a blister
  • The blister may tear and leak clear fluid
  • The blister then dries up and a yellowish scab forms
  • The scab eventually falls away and leaves the slightly raw looking area
  • The virus re-enters it’s dormant state

Complications from the Herpes Simplex Virus

Although this is less common, the herpes simplex virus can produce additional complications in other parts of the body, such as:

  • Fingertips – Both types of HSV can migrate to the fingers, often if the patient has a habit of sucking their fingers.
  • Eyes – This virus has been known to cause conjunctivitis (also known as pinkeye). If an ulcer actually manifests on the eye, it can lead to vision problems or even blindness.
  • The Skin – If you are also living with eczema, then their is a higher risk of these blisters spreading across the body. Some cases even warrant emergency medical attention.
  • Vital Organs – A patient with a weakened immune system might let the virus affect vital organs such as the liver, lungs and brain.

Cold Sore Clinical Trials in Birmingham, Alabama

If you would like to participate in a cold sore clinical trial, our experienced research team will get you enrolled in the most appropriate one. If you have never taken part in one before, we suggest that you spend some time looking through our resource section– available here.

Doctor discusses an upcoming cold sore research study with patient

Interested in cold sore clinical research? Ask your doctor for more information.


Cold sore clinical research participants will receive compensation for travel and time involved. Plus, the following will all be provided free of charge:

  • Physical examinations
  • Study prescribed medication
  • Protocol mandated laboratory tests

Please note that we conduct clinical trials targeted towards a diverse variety of medical conditions at our clinic here in Birmingham. Never experienced a cold sore outbreak? You could still qualify for one of these other clinical trials. If you are interested in helping us advance modern medicine while also earning money for your effort, please give us a call today at (205) 757-8208.

Additional Resources for Cold Sores